HIV/AIDS
Researchers' data from Belgium, Netherlands and Italy advance HIV/AIDS research
Published in AIDS Weekly, May 29th, 2006
Study 1: The integrase cofactor LEDGF/p75 plays a key role in the replication cycle of human immunodeficiency virus and is a potential antiviral target.
Researchers in Belgium report, "After identifying the interaction between the transcriptional co-activator lens epithelium -derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) integrase (IN), we have now investigated the role of LEDGF/p75 during HIV replication. Transient small interfering RNA-mediated knockdown of LEDGF/p75 in HeLaP4 cells resulted in a three- to five-fold inhibition of...
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Source: AIDS Weekly (2006-05-29)
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