Published in AIDS Weekly, June 5th, 2006
Study 1: HIV-1 Vif recognizes APOBEC3G and APOBEC3F by different mechanisms.
According to recent research from the United States, "APOBEC3G (A3G) and related cytidine deaminases, such as APOBEC3F (A3F), are potent inhibitors of retroviruses. Formation of infectious human immunodeficiency virus type 1 (HTV-1) requires suppression of multiple cytidine deaminases by Vif.
"Whether HIV-1 Vif recognizes various APOBEC3 proteins through a common mechanism is unclear. The domains in Vif that mediate APOBEC3 recognitions are also poorly defined. The...
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