HIV/AIDS Pathogenesis
HIV capsid mutations can have deleterious effects on nuclear targeting and integration
Published in AIDS Weekly, June 12th, 2006
According to a recently published report from the United States, "Human immunodeficiency virus type 1 (HIV-1) particles begin their replication upon fusion with the plasma membrane of target cells and release of the viral core into the host cell cytoplasm.
"Soon thereafter, the viral capsid, which is composed of a polymer of the CA protein, disassociates from the internal ribonucleoprotein complex. While this disassembly process remains poorly understood, the available evidence indicates that proper uncoating of the core is a key step in infection."
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Source: AIDS Weekly (2006-06-12)
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