AIDS Weekly

HIV/AIDS Drug Development - Phosphorothioate oligonucleotides inhibit HIV-1 fusion by blocking gp41 core formation

HIV/AIDS HAART - Genotype-guided HAART in early infection may be effective against drug-resistant HIV-1

HIV/AIDS HAART - Lopinavir and ritonavir have limited penetration in the male genital tract

HIV/AIDS Pneumonia - HIV+ children with severe pneumonia fail treatment more often than uninfected children

HIV/AIDS Vaginal Microbicide - Synthetic-2 RANTES effective and nontoxic as a CCR5-targeted vaginal microbicide

Anemia - Iron supplement does not increase hemoglobin and ferritin levels in malaria-prevalent area

Awards - Merck & Co. receives Global Business Coalition on HIV/AIDS award for combating pandemic in Botswana

Business & Finance - CytRx reports net loss of $4.2 million in first quarter

Business Update - Chimerix acquires lead compound library of antiviral agents from University of Michigan

Clinical Trials - Health Enhancement Products begins HIV and CRP clinical trials in Cameroon

Cytomegalovirus Infection - HCV infection elicits glycoprotein M/gN-specific virus-neutralizing antibody response

Disease Associations - Hepatitis C virus linked to occurrence of cryoglobulinemia

Drug Development - Benzodithiazine-dioxides with antitumor and anti-HIV activities synthesized

Finance - Monogram announces the closing of Pfizer's $25 million investment

HIV/AIDS & Mental Illness - Male veterans with severe mental illness have inaccurate HIV knowledge

HIV/AIDS HAART - Early site supervision increases patient recruitment for HAART initiation

HIV/AIDS HAART - Lamivudine monotherapy effective in patients with lamivudine-resistant HIV-1

HIV/AIDS HAART - Latin American and African countries have better HAART coverage than predicted

HIV/AIDS HAART - Single combination once-daily pill with tenofovir and emtricitabine is cost-effective

HIV/AIDS HAART - Those with undetected viremia have incomplete immune reconstitution after 1 year of HAART

HIV/AIDS Immunity - IL-2 helps restore innate natural killer T cell immunity in primary HIV-1 infection

HIV/AIDS Microbicide - UC781 is a microbicidal against NNRTI-resistant HIV-1 in a dose-dependent manner

HIV/AIDS Pathogenesis - HIV-1 RT-nucleocapsid protein interactions play critical roles in HIV-1 variability

HIV/AIDS Pathogenesis - HMBA remodels HIV-1 LTR and induces tat-independent HIV-1

HIV/AIDS Pathogenesis - Large HIV-specific CD8+ CTL clones maintain high frequencies of memory CTL after HAART

HIV/AIDS Pathogenesis - Tubulin-mediated binding of HIV-1 Tat to cytoskeleton causes neuronal damage

HIV/AIDS Pathogenesis - Two wild-type subunits within HIV-1 env glycoprotein trimer required to support virus entry

HIV/AIDS Pathogenesis - Viral DNA analogs probe HIV-1 integrase/DNA interactions

HIV/AIDS Research - New study calculates millions of years saved in lives of AIDS patients

HIV/AIDS Research - Research produces images of AIDS virus that may shape vaccine

HIV/AIDS Research - Rhesus monkeys in Nepal may provide new alternative for HIV/AIDS research

HIV/AIDS Therapy - COX-2 inhibitors improve markers for persistent immune activation in HIV/AIDS

HIV/AIDS Therapy - Large-scale simplified HAART programs are successful in rural Africa

HIV/AIDS Therapy - New protein target may advance design of HIV and cancer drugs

HIV/AIDS Therapy - Strong HIV prevention programs provide lessons for effective interventions

HIV/AIDS Therapy - U.S. Food and Drug Administration gives tentative approval to new generic AIDS drug

HIV/AIDS Transmission - HIV-1 not recovered from homemade injectable opiates

HIV/AIDS Vaccine - RNAi is developed as treatment for HIV-1 infection

HIV/AIDS Vaccine - Statistical evaluation program narrows HIV vaccine candidates for efficacy trials

HIV/AIDS Vaccine - Studies on expression and immunogenicity of HIV vaccine are reported

HIV/AIDS Vertical Transmission - Zidovudine exposure in utero associated with lower birth weight but effects fade over time

HIV/Hepatitis C Coinfection - HAART increases hepatoxicity risk in HIV/hepatitis C-coinfected hemophiliacs

HIV/Leishmaniasis Coinfection - Oral miltefosine successfully treats postkala-azar dermal leishmaniasis after HAART

Hepatitis B Virus - HBV lamivudine resistance does not affect therapy in HIV-HBV co-infection

Hepatitis C Virus - HCV quasispecies variability is influenced by HIV infection and therapy

Hepatitis C Virus - Hepatitis C virus does not affect immune responses to HAART in HIV/HCV-coinfected patients

Liver Cancer - Liver tumor angiogenesis is blocked by the protease inhibitor indinavir

Lymphoma - NF-kappa B is essential for progression of KSHV- and EBV-infected lymphomas

Pediatrics HIV/AIDS Comorbidity - Comorbidities cause death in children hospitalized with diarrheal disease