HIV/AIDS Drug Development
Phosphorothioate oligonucleotides inhibit HIV-1 fusion by blocking gp41 core formation
Published in AIDS Weekly, June 19th, 2006
According to recent research from Canada, "Several studies have shown that phosphorothioate oligodeoxynucleotides (PS-ONs) have a sequence-independent antiviral activity against human immunodeficiency virus type 1 (HIV-1).
"It has also been suggested that PS-ONs inhibit HIV-1 by acting as attachment inhibitors that bind to the V 3 loop of gpl20 and prevent the gp120-CD4 interaction."
"Here we show that PS-ONs (and their fully 2 '-O-methylated derivatives) are potent inhibitors of HIV-1-mediated membrane fusion and HIV-1 replication in a...
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Source: AIDS Weekly (2006-06-19)
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