HIV/AIDS HAART
Lopinavir and ritonavir have limited penetration in the male genital tract
Published in AIDS Weekly, June 19th, 2006
"The concentrations of lopinavir and ritonavir in seminal and blood plasma and the seminal human immunodeficiency virus (HIV) viral load were quantified by HPLC and the Nuclisens assay, respectively, in a cross-sectional study of 16 HIV-1-infected Brazilian men under stable treatment with a lopinavir/ritonavir containing antiretroviral regimen.
"Semen and blood samples were collected on 2 occasions: at 6 to 60 minutes before ('trough'), and 5 to 6 hours after ('peak') ingestion of regular doses of lopinavir/ritonavir," wrote investigators in Brazil.
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Source: AIDS Weekly (2006-06-19)
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