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Cancer Research

Results of TNX-355 combination study published in Antimicrobial Agents and Chemotherapy

Published in AIDS Weekly, June 26th, 2006

Results from a study of Tanox's (TNOX) viral-entry inhibitor antibody, TNX-355, demonstrate the investigational agent's synergy with the only currently approved viral-entry inhibitor, enfuvirtide.

Synergistic antiviral activity between the two agents was demonstrated against both laboratory and clinical strains of HIV-1 using conventional in vitro techniques. The research demonstrates TNX-355's ability to act synergistically with another drug targeting an early step in the entry cascade and supports the strategy of combining therapies directed at sequential steps of the viral-entry process. Agents are defined as synergistic when the activity seen in combination is...

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