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Hepatitis C Virus

HIV/HCV coinfection virological responders differentiated from nonresponders

Published in AIDS Weekly, July 3rd, 2006

According to recent research from the United States, the pharmacodynamics of pegylated interferon (PEG-IFN) alpha differentiate HIV/hepatitis C virus (HCV) coinfected sustained virological responders from nonresponders.

"PEG-IFN has become standard therapy for HCV infection. We evaluated whether PEG-IFN pharmacodynamics and pharmacokinetics account for differences in treatment outcome and whether these parameters might be predictors of therapeutic outcome," wrote A.H. Talal and colleagues, Cornell University.

"Twenty-four IFN-naive, HCV/human immunodeficiency virus-coinfected patients received PEG-IFN alpha-2b (1-5 mcg/kg) once weekly plus daily...

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