Published in AIDS Weekly, July 3rd, 2006
"Since alpha,gamma-diketo acid (DKA) compounds were identified as potent and selective inhibitors for HIV integrase, numerous structural modification studies have been carried out to search for a clinical candidate as a supplement for the highly active antiretroviral therapy regimen.
"Due to the lack of structural information on inhibitor-integrase interactions, a comprehensive structure-activity relationship study is necessary," researchers in the United States report.
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