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HIV/AIDS Vertical Transmission

Perinatal HIV transmission may be prevented by neutralizing antibodies

Published in AIDS Weekly, July 10th, 2006

Neutralizing antibodies may help prevent perinatal HIV transmission via passive immunoprophylaxis.

According to a study from France, "We analyzed the association between mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) and maternal neutralizing antibodies to heterologous primary isolates of various HIV-1 clades, to test the hypothesis that protective antibodies are those with broad neutralizing activity.

"Our study sample included 90 Thai women for whom the timing of HIV-1 transmission (in utero or intrapartum) was known. The statistical analysis included a conditional logistic-regression model to control for both...

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