Published in AIDS Weekly, July 10th, 2006
Study 1: Cells knocked-out for Lens epithelium-derived growth factor (LEDGF)/p75 and/or hepatoma-derived growth factor related protein 2 (HRP2) will be useful genetic tools to address the roles of these host cell factors in human immunodeficiency virus type 1 (HIV-1) replication.
According to recent research published in the journal Virology, "Human immunodeficiency virus type 1 integrase (IN) functions in cells within the context of high molecular weight preintegration complexes (PICs). Lens epithelium-derived growth factor (LEDGF) transcriptional coactivator/p75 and...
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