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HIV/Leishmania Coinfection

HIV-1 indirectly affects uptake of Leishmania inside monocyte-derived macrophages

Published in AIDS Weekly, July 10th, 2006

HIV-1 indirectly affects the uptake of Leishmania parasites inside monocyte-derived macrophages.

"Concurrent uncontrolled development of human immunodeficiency virus type 1 (HIV-1) and Leishmania spp. is regarded as an emerging pathogenic combination in countries where human beings are exposed to these two micro-organisms.

"The present study was aimed at exploring whether HIV-1 development within a culture of human monocyte-derived macrophages (MDMs) affected the further development of luciferase-encoding Leishmania infantum using the luciferase activity as a readout assay," scientists in Canada report.

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