HIV/AIDS

Researchers' data from Japan and the United States advance HIV/AIDS research

Published in AIDS Weekly, July 24th, 2006

Data on HIV/AIDS are outlined in reports from Japan and the United States.

Study 1: AP-4 may be responsible for the transcriptional quiescence of latent HIV-1 provirus.

According to a study from Japan, "Elucidation of the mechanism of transcriptional silencing of human immunodeficiency virus type 1 (HIV-1) provirus in latently infected cells is crucial to understand the pathophysiology of HIV-1 infection and to develop novel therapies.

"Here we demonstrate that AP-4 is responsible for the transcriptional repression of HIV-1. We found that AP-4 site within the viral long terminal repeat (LTR) is well conserved in the majority of...

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Source: AIDS Weekly (2006-07-24)

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