Published in AIDS Weekly, July 24th, 2006
Study 1: AP-4 may be responsible for the transcriptional quiescence of latent HIV-1 provirus.
According to a study from Japan, "Elucidation of the mechanism of transcriptional silencing of human immunodeficiency virus type 1 (HIV-1) provirus in latently infected cells is crucial to understand the pathophysiology of HIV-1 infection and to develop novel therapies.
"Here we demonstrate that AP-4 is responsible for the transcriptional repression of HIV-1. We found that AP-4 site within the viral long terminal repeat (LTR) is well conserved in the majority of...
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