HIV/AIDS Phenotyping
HIV envelope V3 sequences predicts phenotype for HIV-1 subtype C
Published in AIDS Weekly, July 31st, 2006
According to a study from the United States, "In human immunodeficiency virus type 1 (HIV-1) subtype B infections, the emergence of viruses able to use CXCR4 as a coreceptor is well documented and associated with accelerated CD4 decline and disease progression.
"However, in HIV-1 subtype C infections, responsible for more than 50% of global infections, CXCR4 usage is less common, even in individuals with advanced disease."
"A reliable phenotype prediction method based on genetic sequence analysis could provide a rapid and less expensive approach to identify possible...
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Source: AIDS Weekly (2006-07-31)
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