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HIV-2 Infection

Maintenance of HIV-specific CD4 cells delay disease progression in HIV-2 infection

Published in AIDS Weekly, August 7th, 2006

Maintenance of HIV-specific CD4 cells is associated with delayed disease progression in HIV-2 infection.

According to a recently published report from England, "Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response.

"To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians."

"Using cytokine flow cytometry and lymphoproliferation assays," said the authors, "we show that HIV-specific CD4+ T cells from...

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