HIV/AIDS Drug Resistance
HIV-1 RT K65R and thymidine analog mutations exhibit bidirectional phenotypic antagonism
Published in AIDS Weekly, August 7th, 2006
According to a study from the United States, "The K65R mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is selected in vitro by many D-nucleoside analog RT inhibitors (NRTI) but has been rarely detected in treated patients.
"In recent clinical trials, the K65R mutation has emerged frequently in patients experiencing virologic failure on antiretroviral combinations that do not include 3'-azidothymidine (AZT). The reason for this change is uncertain."
"To gain insight, we examined trends in...
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Source: AIDS Weekly (2006-08-07)
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