HIV/AIDS Pathogenesis
HIV-1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes
Published in AIDS Weekly, August 14th, 2006
"Previous examination of the effect of TCF-4 on transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in human astrocytic cells found that TCF-4 affects the HIV-1 promoter through the GC-rich domain (nt -80 to nt -68). Here, the physical interaction and a functional consequence of TCF4-Sp1 contact were characterized," investigators in the United States report.
According to researchers, "It was shown that expression of TCF-4 in U-87 MG (human astrocytic) cells decreased basal and Sp1-mediated transcription of the HIV-1 promoter. Results from a GST pull-down assay,...
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Source: AIDS Weekly (2006-08-14)
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