HIV/AIDS Drug Development
HIV-1 replication suppressed by arginine deiminase of Mycoplasma arginini
Published in AIDS Weekly, August 21st, 2006
"It was found previously that human immunodeficiency virus type 1 (HIV-1)-irrelevant CD8+ cytotoxic T lymphocytes (CTLs) from uninfected donors suppressed HIV-1 replication in a cell-contact-dependent manner.
"However, one of these CTL lines (CTL-3) also significantly suppressed HIV-1 replication through its supernatant," scientists in Japan report.
According to M. Kubo and colleagues at Tokyo Medical & Dental University, "Here, the suppressive fraction from CTL-3 supernatant was purified and analyzed by mass spectrometry.
"A protein...
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Source: AIDS Weekly (2006-08-21)
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