HIV/AIDS Pathogenesis
HIV protease cleaves poly(A)-binding protein
Published in AIDS Weekly, August 21st, 2006
According to recent research from Spain, "The PABP [poly(A)-binding protein] is able to interact with the 3' poly(A) tail of eukaryotic mRNA, promoting its translation.
"Cleavage of PABP by viral proteases encoded by several picomaviruses and caliciviruses plays a role in the abrogation of cellular protein synthesis."
"We report that infection of MT-2 cells with HIV-1 leads to efficient proteolysis of PABP," wrote E. Alvarez and colleagues at the Universidad Autonoma, Cantoblanco in Madrid.
"Analysis of PABP integrity was carried out in BHK-21 (baby-hamster kidney)...
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Source: AIDS Weekly (2006-08-21)
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