HIV/AIDS Drug Development

Antifungal protein isolated from the pea inhibits HIV-1 reverse transcriptase

Published in AIDS Weekly, September 11th, 2006

An antifungal protein isolated from the pea Pisum sativum var. arvense Poir inhibits HIV-1 reverse transcriptase.

"An antifungal protein with a molecular mass of 11 kDa and a lysine-rich N-terminal sequence was isolated from the seeds of the pea Pisum sativum var. arvense Poir," scientists writing in the journal Peptides report.

According to H.X. Wang and colleagues at the Chinese University of Hong Kong, "The antifungal protein was unadsorbed on DEAE-cellulose but adsorbed on Affi-gel blue gel and CM-cellulose.

"It exerted antifungal activity against Physalospora piricola with an IC₅₀ of...

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Source: AIDS Weekly (2006-09-11)

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