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HIV/AIDS Pathogenesis

Antibody maturation not seriously disrupted in germinal centers during early HIV infection

Published in AIDS Weekly, September 11th, 2006

Antibody maturation is not seriously disrupted in germinal centers during the early stages of HIV infection.

According to a recently published study from the United States, "Infection with HIV-1, SIV, or simian HIV is associated with abnormalities in the number, size, and structure of germinal centers (GCs).

"To determine whether these histopathologic abnormalities are associated with abnormalities in Ab development, we analyzed nucleotide sequences of Igs from splenic GCs of simian HIV-infected macaques."

"Virus-specific GCs were identified in frozen splenic tissue sections by inverse immunohistochemistry using rHIV-1 gp120 as a...

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