Published in AIDS Weekly, September 18th, 2006
Study 1: Cyclophilin A alters HIV-1 sensitivity to a TRIM5 alpha-independent innate immune pathway.
"TRIM5 alpha is an important mediator of antiretroviral innate immunity influencing species-specific retroviral replication. Here we investigate the role of the peptidyl prolyl isomerase enzyme cyclophilin A in TRIM5 alpha antiviral activity.
"Cyclophilin A is recruited into nascent human immunodeficiency virus type 1 (HIV-1) virions as well as incoming HIV-1 capsids, where it isomerizes an exposed proline residue," wrote investigators in...
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