Published in AIDS Weekly, September 25th, 2006
Study 1: Preferential infection shortens the lifespan of HIV-1-specific CD4+ T cells.
"CD4+ T-cell help is essential for effective immune responses to viruses. In human immunodeficiency virus (HIV) infection, CD4+ T cells specific for HIV are infected by the virus at higher frequencies than other memory CD4+ T cells," researchers in the United States report.
According to the authors, "Here, we demonstrate that HIV-specific CD4+ T cells are barely detectable in most infected individuals and that the corresponding CD4+ T cells exhibit an immature phenotype...
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