HIV/AIDS Prevention
Early steps of HIV-1 replication inhibited by integration with viral integrase
Published in AIDS Weekly, October 2nd, 2006
"To replicate, HIV-1 needs to integrate a cDNA copy of its RNA genome into a chromosome of the host cell, a step controlled by the viral IN protein. Viral integration involves the participation of several cellular proteins.
"SNF5/Ini1, a subunit of the SWI/SNF chromatin remodeling complex, was the first cofactor identified to interact with IN. We report here that SNF5/Ini1 interferes with early steps of HIV-1 replication," wrote M. Maroun and colleagues,...
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Source: AIDS Weekly (2006-10-02)
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