HIV/AIDS Pathogenesis
HIV-1 integration in untreated infection occurs preferentially within genes
Published in AIDS Weekly, October 2nd, 2006
According to a study from the United States, "Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes.
"We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections."
"The great majority of integration sites in each tissue were within genes....
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Source: AIDS Weekly (2006-10-02)
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