HIV/AIDS Pathogenesis
TRIMCyp-mediated HIV-1 infection block occurs before earliest step of reverse transcription
Published in AIDS Weekly, October 16th, 2006
According to recent research from the United States, "In owl monkeys, a retrotransposition event replaced the gene encoding the retroviral restriction factor TRIM5 alpha with one encoding TRIMCyp, a fusion between the RING, B-box 2 and coiled-coil domains of TRIM5 and cyclophilin A.
"TRIMCyp restricts human immunodeficiency virus (HIV-1) infection by a mechanism dependent on the interaction of the cyclophilin A moiety and the HIV-1 capsid protein."
"Here, we show that infection by retroviruses other than HIV-1 can be restricted by...
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Source: AIDS Weekly (2006-10-16)
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