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HIV/AIDS Vaccine

HIV vaccine reduces per-exposure probability of infection during repeated challenges

Published in AIDS Weekly, October 16th, 2006

HIV-1 DNA/MVA vaccination reduces the per-exposure probability of infection during repeated mucosal SHIV challenges

According to a report from the United States, "Historically, HIV vaccines specifically designed to raise cellular immunity resulted in protection from disease progression but not infection when tested in monkeys challenged with a single high virus exposure. An alternative approach, more analogous to human sexual exposures, is to repetitively challenge immunized monkeys with a much lower dose of virus until systemic infection is documented."

"Using these conditions to mimic human sexual transmission, we found that a multi-protein DNA/MVA...

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