Kaposi Sarcoma-Associated Herpesvirus
Intracellular-activated Notch1 reactivates Kaposi sarcoma-associated herpesvirus from latency
Published in AIDS Weekly, October 16th, 2006
"Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a predominantly latent infection in the infected host. Importantly, during latency, only a small number of viral encoded genes are expressed.
"This viral gene expression pattern contributes to the establishment of long-term infection as well as the ability of the virus to evade the immune system," researchers in the United States report.
According to the authors, "Previous studies have been shown that the replication and transcription activator (RTA) encoded by ORF50...
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Source: AIDS Weekly (2006-10-16)
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