HIV/AIDS
Data from the United States and Canada advance knowledge in HIV/AIDS research
Published in AIDS Weekly, October 16th, 2006
Study 1: Efavirenz and 8-hydroxyefavirenz metabolism by P4502B6 leads to inactivation by two distinct mechanisms.
"Efavirenz is a non-nucleoside human immunodeficiency virus (HIV)-1 reverse transcriptase inhibitor used in combination therapy to treat HIV-1. Efavirenz metabolism is catalyzed primarily by the polymorphic enzyme P450 2B6," researchers in the United States report.
According to scientists, "Metabolism of efavirenz by P450 2B6 and the naturally occurring P450 2B6.4 mutant led to the formation of 8-hydroxyefavirenz. Efavirenz inactivated...
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Source: AIDS Weekly (2006-10-16)
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