HIV/AIDS
Research from Institute of Infectious Disease, Infectious Diseases Department provides new data on HIV/AIDS
Published in AIDS Weekly, December 4th, 2006
Research findings, "Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages," are discussed in a new report. "Although successful attempts to inhibit HIV-1 replication in T cells using RNAi have been reported, the effect of HIV-specific RNAi on macrophages is not well known. Macrophages are key targets for anti-HIV-1 therapy because they are able to survive long after the initial infection with HIV and can spread the virus to T cells," scientists in Tokyo, Japan report.
"In this study, we identified a putative RNAi target of HIV, consisting of the portion of the nef gene...
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Source: AIDS Weekly (2006-12-04)
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