HIV/AIDS Cancer
Recent findings from University of Pennsylvania, Department of Microbiology highlight research in HIV/AIDS cancer
Published in AIDS Weekly, January 1st, 2007
A report, "Functional characterization of Kaposi's sarcoma-associated herpesvirus ORF45 by bacterial artificial chromosome-based mutagenesis," is newly published data in The Journal of Virology. "Open reading frame 45 (ORF45) of Kaposi's sarcoma-associated herpesvirus (KSHV) encodes an immediate-early protein. This protein is also present in virions as a tegument protein," scientists writing in the Journal of Virology report.
"ORF45 protein interacts with interferon regulatory factor 7 (IRF-7) and inhibits virus-induced type I interferon production by blocking activation of IRF-7. To define further the function of ORF45 and the mechanism underlying its action, we...
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Source: AIDS Weekly (2007-01-01)
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