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HIV/AIDS Therapy

Panacos announces first cohort results of Phase IIb study of bevirimat

Published in AIDS Weekly, January 15th, 2007

Panacos Pharmaceuticals, Inc. (PANC) announced preliminary results from the first cohort of a Phase IIb study of bevirimat (PA-457) in patients failing HIV therapy due to drug resistance.

The data confirm the clinical antiviral activity of bevirimat shown in previous studies; however, the bevirimat plasma concentrations were lower than anticipated, suggesting that the tablet formulation used for this study did not deliver the drug as expected.

After 14 days of dosing with 400 mg of bevirimat tablets administered on top of patients' failing background regimens, an antiviral effect was seen in the bevirimat treatment group. Two out of twelve patients...

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