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Smallpox Vaccine

Bavarian Nordic reports preliminary data from phase II study with Imvamune

Published in AIDS Weekly, January 22nd, 2007

Bavarian Nordic A/S announced preliminary results from a phase II study with Imvamune in HIV infected subjects in the company's development program for Imvamune as a safe third-generation MVA smallpox vaccine.

The completed phase II study compared the safety and immunogenicity of Imvamune in 91 HIV infected subjects (CD4 > 350 cells/microl) to 60 healthy subjects. The study demonstrated that Imvamune is as equally well tolerated in HIV infected and healthy subjects.

Importantly, the immunogenicity data also revealed that 96% of HIV infected subjects previously not vaccinated against smallpox had a detectable antibody response 2 weeks after the...

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