Published in AIDS Weekly, February 5th, 2007
Study 1: Research findings, "A novel in vitro system to generate and study latently HIV-infected long-lived normal CD4+ T-lymphocytes," are discussed in a new report. "Studies of mechanisms of HIV-latency and its reactivation in long-lived resting CD4+ T-lymphocytes in patients have been limited due to the very low frequency of these cells (approximately 1-10 cells per 106 CD4+ T-cells). To circumvent this obstacle, an in vitro culture system for post-activation long-term survival of normal CD4+ T-cells in a quiescent (non-cycling) state was developed and used to generate latently infected,...
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