HIV/AIDS Therapy
Research reports on HIV/AIDS therapy from University of Urbino, Institute of Biochemistry provide new insights
Published in AIDS Weekly, May 21st, 2007
Scientists discuss in "Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir" new findings in HIV/AIDS. According to recent research from Urbino, Italy, "(i) To generate a new heterodinucleotide (3TCpPMPA) comprising the drugs lamivudine and tenofovir which have been shown to act synergistically and (ii) to protect macrophages from 'de novo' HIV-1-infection through its administration. 3TCpPMPA was obtained by coupling the morpholidate derivative of tenofovir with the mono n-tri-butylammonium salt of lamivudine 5'-monophosphate."
"Stability and metabolism were evaluated in vitro and in vivo in mice. 3TCpPMPA was encapsulated...
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Source: AIDS Weekly (2007-05-21)
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