HIV/AIDS
Researchers at University of Paris have published new data on HIV/AIDS
Published in AIDS Weekly, June 11th, 2007
Fresh data on HIV/AIDS are presented in the report "Involvement of the betaTrCP in the ubiquitination and stability of the HIV-1 Vpu protein. The human immunodeficiency virus type 1 (HIV-1) Vpu protein binds to the CD4 receptor and targets it to the proteasome for degradation. This process requires the recruitment of human betaTrCP, a component of the Skp1-Cullin-F box (SCF) ubiquitin ligase complex, that interacts with phosphorylated Vpu molecules," scientists writing in the journal Biochemical and Biophysical Research Communications report.
"Vpu, unlike other ligands of betaTrCP, has never been reported to be degraded. We provide evidence that Vpu, itself, is...
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Source: AIDS Weekly (2007-06-11)
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