HIV/AIDS Therapy
Studies from Tel-Aviv University yield new data on HIV/AIDS therapy
Published in AIDS Weekly, June 18th, 2007
New research, "De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants," is the subject of a report. "We used molecular modeling to design de novo broad-range inhibitors against wild type and drug-resistant variants of the reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1). First, we screened for small fragments that would interact with each one of four RT structures (one wild type and three mutants)," investigators in Tel Aviv, Israel report.
"Then, these fragments were linked to build a scaffold molecule. Out of 27 different compounds...
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Source: AIDS Weekly (2007-06-18)
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