Gene Therapy
New gene therapy study results reported from Paul-Ehrlich-Institute
Published in AIDS Weekly, July 23rd, 2007
New investigation results, "Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells," are detailed in a study published in Virology. "Although lentiviruses like HIV-1 are able to infect non-dividing cells, particular resting cells such as non-stimulated primary peripheral blood mononuclear cells (PBMC) are resistant to infection. In contrast to other lentiviruses, SIVsmmPBj can replicate in non-stimulated PBMC," scientists in Langen, Germany report.
"Moreover, SIVsmmPBj-derived, but not HIV-1-derived, replication-incompetent vectors enable gene transfer into G(0)-arrested human cell lines and primary human monocytes. Here,...
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Source: AIDS Weekly (2007-07-23)
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