HIV/AIDS Therapy
Reports outline HIV/AIDS therapy study findings from Murdoch University, Center for Clinical Immunology and Biomedical Statistics
Published in AIDS Weekly, July 30th, 2007
Data detailed in "Immune responses to abacavir in antigen-presenting cells from hypersensitive patients" have been presented. "A potentially life-threatening hypersensitive reaction accompanies the use of HIV nucleoside analogue abacavir (ABC) in 4-8% of Caucasian individuals. HLA-B*5701 and Hsp70 493T alleles have been shown to predict susceptibility to this hypersensitivity. This study was undertaken to provide a mechanistic understanding of the highly significant genetic association of HLA Class I and Hsp70 alleles with ABC hypersensitivity," investigators in Perth, Australia report.
"In this study an ABC-induced localization of intracellular HSP70 to endosomal...
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Source: AIDS Weekly (2007-07-30)
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