HIV/AIDS

Major breakthrough in understanding how HIV interferes with infected cell division

Published in AIDS Weekly, July 30th, 2007

Dr. Éric A. Cohen, a researcher at the IRCM (Institut de recherches cliniques de Montréal), and his team will publish on Friday, July 13, in PLoS Pathogens a discovery that could lead to the development of a new class of drugs to combat HIV.

Human immunodeficiency virus type 1 (HIV-1) causes AIDS by depleting essential immune cells called CD4+T lymphocytes in infected individuals, resulting in a compromised immune system. At the center of this process is the HIV protein, viral protein R (Vpr), which stops infected CD4+T cells from dividing and as a consequence compromises their immune function. In addition, by arresting cell division, Vpr helps HIV to harness the...

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Source: AIDS Weekly (2007-07-30)

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