HIV/AIDS
New HIV/AIDS study findings have been reported by K. Mantelingu and co-researchers
Published in AIDS Weekly, August 13th, 2007
A new study, "Specific inhibition of p300-HAT alters global gene expression and represses HIV replication," is now available. "Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS, and cardiac hypertrophy," scientists writing in the journal Chemistry & Biology report.
"We describe the synthesis and characterization of a set of p300-HAT-specific small-molecule inhibitors from a natural nonspecific HAT inhibitor, garcinol, which is highly toxic to cells. We show that the specific...
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Source: AIDS Weekly (2007-08-13)
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