HIV/AIDS Therapy
Study findings on HIV/AIDS therapy are outlined in reports from University of Washington, Department of Pharmaceutics
Published in AIDS Weekly, September 24th, 2007
A new study, "Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid," is now available. According to recent research published in the journal Drug Metabolism and Disposition, "P-glycoprotein (P-gp) expression at the rodent blood-brain barrier (BBB) limits the central nervous system (CNS) distribution of anti-human immunodeficiency virus (HIV) protease inhibitors (PIs). However, it is not clear whether P-gp activity at the human BBB is as effective as that in rodents in preventing the distribution of PIs into the CNS."
"If it is, inhibition of P-gp at...
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Source: AIDS Weekly (2007-09-24)
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