HIV/AIDS

Research on HIV/AIDS detailed by scientists at University of Oxford

Published in AIDS Weekly, October 22nd, 2007

According to a study from Oxford, the United Kingdom, "'HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type I (HIV-1) infection."

"Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope," wrote H. Crawford and colleagues, University of Oxford.

The researchers concluded: "These data may help explain...

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Source: AIDS Weekly (2007-10-22)

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