Published in AIDS Weekly, October 22nd, 2007
"Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope," wrote H. Crawford and colleagues, University of Oxford.
The researchers concluded: "These data may help explain...
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