Published in AIDS Weekly, November 19th, 2007
"To study the mechanism by which this enzyme makes frequent errors, we have developed and used a set of variably sized nonpolar uridine analogues (rH, rF, rL, rB) in RNAs to probe its functional steric flexibility in nucleotide incorporation. Our kinetics studies show that the enzyme pairs all the analogues selectively with adenine, with a preference for dichloro analogues. However,...
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