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HIV/AIDS Cell Biology

New findings in HIV/AIDS cell biology described by A. Foli and co-researchers

Published in AIDS Weekly, November 26th, 2007

Fresh data on HIV/AIDS are presented in the report 'A checkpoint in the cell cycle progression as a therapeutic target to inhibit HIV replication.' According to recent research from Pavia, Italy, "Human immunodeficiency virus (HIV) expression is boosted after T lymphocyte stimulation. It is not known, however, in which phase(s) of the cell cycle HIV is maximally expressed."

"We demonstrate here that cell activation induces limited HIV expression and that progression to cell proliferation is required for optimal HIV replication. We also show that the G1/S cell cycle transition is a critical checkpoint in this process and that limiting progression at this step with...

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