Cancer

Study findings from National Cancer Institute broaden understanding of cancer

Published in AIDS Weekly, December 31st, 2007

"A new compound, 1,3,4,5-tetragalloylapiitol (1), was isolated from the aqueous extract of the plant Hylodendron gabunensis and was found to be a potent inhibitor of RNase H enzymatic activity," scientists in the United States report.

"The structure of 1 was elucidated by NMR analyses to be an apiitol (2) sugar moiety substituted with four gallic acid residues. Optical rotation measurements of the free sugar following basic hydrolysis indicated that the 3S absolute configuration was the same as that Of D-apiitol," wrote K. Takada and colleagues, National Cancer Institute.

The researchers concluded: "Compound I inhibited HIV-1, HIV-2, and human RNase...

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Source: AIDS Weekly (2007-12-31)

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