HIV/AIDS
Genomic screen nets hundreds of human proteins exploited by HIV
Published in AIDS Weekly, January 28th, 2008
BOSTON, Mass. (Jan. 10, 2008) — In some ways, HIV resembles a minimalist painter, using a few basic components to achieve dramatic effects. The virus contains just nine genes encoding 15 proteins, which wreak havoc on the human immune system. But this bare bones approach could have a fatal flaw. Lacking robust machinery, HIV hijacks human proteins to propagate, and these might represent powerful therapeutic targets.
Using a technique called RNA interference to screen thousands of genes, Harvard Medical School researchers have now identified 273 human proteins required for HIV propagation. The vast majority had not been connected to the virus by previous studies. The...
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Source: AIDS Weekly (2008-01-28)
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