HIV/AIDS Immunology

Scientists at University of Lisboa target HIV/AIDS immunology

Published in AIDS Weekly, February 4th, 2008

Research findings, 'Monocyte-mediated T cell suppression by HIV-2 envelope proteins,' are discussed in a new report. According to recent research from Lisboa, Portugal, "HIV-2 is associated with an attenuated form of HIV disease. We investigate here the immunosuppressive effects of the HIV-2 envelope protein, gp105."

"We found that gp105 suppresses activation of T cells through a monocyte-mediated mechanism. Suppression of T cell activation by gp105 depends on contact between monocytes and T cells, but not on CD4+CD25+ T cells. The TLR4 pathway is likely involved, since gp105 activates TLR4 signaling and induces TNF-alpha production by monocytes. Immunosuppression is...

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Source: AIDS Weekly (2008-02-04)

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