HIV/AIDS

Findings from A. Sacchi et al in HIV/AIDS reported

Published in AIDS Weekly, February 4th, 2008

"Monocyte differentiation into dendritic cells (DCs) depends on microenvironmental conditions. In this study, the capacity of human monocytes to differentiate into mature DCs and their ability to induce an antiviral immune response was investigated in HIV-infected patients," researchers in Rome, Italy report.

"In healthy subjects, monocytes differentiate into CD1a(+) DCs in the presence of granulocyte macrophage colonystimulating factor and interleukin (IL)-4 and matured in the presence of lipopolysaccharide. Here, we found that in 30% and 45% of HIVinfected white and African subjects, respectively, monocytes gave rise to a homogeneous CD1a(-) DC population. In the...

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Source: AIDS Weekly (2008-02-04)

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