HIV/AIDS

Reports from Ben-Gurion University advance knowledge in HIV/AIDS

Published in AIDS Weekly, February 25th, 2008

According to a study from Beer Sheva, Israel, "Impairment of neutrophil functions and high levels of apoptotic neutrophils have been reported in human immunodeficiency virus (HIV) patients. The aim of the present study was to investigate the direct in vitro effects of the different HIV protease inhibitors (PIS) on neutrophil functions and apoptosis and to explore their mechanisms of action."

"The effects of nelfinavir (NFV), saquinavir (SQV), lopinavir (LPV), ritonavir (RTV), and amprenavir (APV) in the range of 5 to 100 mu g/ml on neutrophil function, apoptosis, and R-calpain activity were studied. The neutrophil functions studied included superoxide production...

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Source: AIDS Weekly (2008-02-25)

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